Our multidisciplinary research team includes experts in epidemiology, clinical research, biological sciences, technology development and optometry, ophthalmology and opticianary – all with relentless and insatiable passion for public health.
Clinical Research and Trial Services
Dedicated clinical research teams aim to identify and understand clinical problems by evaluating the performance of contemporary products.
We have the capacity, technical expertise and experience to generate effective product-based solutions.
Extensive laboratory facilities and the expertise of the scientific team provide a vital adjunct by enabling in-depth evaluation of the interaction between products and the ocular environment.
Clinical research activities are dedicated to developing and testing products for vision correction, including:
- Contact lenses
- Contact lens solutions
- New instruments and techniques.
With our technology team we have developed specialised instruments and software for our clinical research, including electronic vision charts for distance, intermediate and near testing and a customised clinical database.
We also possess cutting-edge commercial instruments, such as optical coherence tomography and laser interferometric biometry.
Standards and Guidelines
All optometrists are highly qualified, required to demonstrate concordance at regular intervals, and undergo regular training to maintain and enhance general and specialised optometric skills.
Local and international regulations and guidelines met include:
- National Statement on Ethical Conduct in Human Research
- Access to Unapproved Therapeutic Goods
- Good Clinical Practice
- Declaration of Helsinki.
In addition to our Sydney clinical trials centre, we have a clinical research facility at Brien Holden Vision Institute China in Guangzhou. We currently have more than 2,500 and 1,200 active participants listed on our Sydney and Guangzhou facilities respectively.
We also have access to overseas collaborators for trials that require special populations or a larger sample size.
CLINICAL RESEARCH MANAGER
Daniel received his Bachelor of Optometry with Honours in 1990, his Master of Optometry in 1999 and Graduate Certificate in Ocular Therapeutics in 2012, all from the University of New South Wales (UNSW), Sydney, Australia.
Daniel spent 16 years in private practice before joining the Brien Holden Institute in 2006. He has also been a clinical supervisor at the School of Optometry and Vision Science, University of New South Wales since 1994.
Daniel has published on a variety of ophthalmic topics, including ocular pathology, contact lens case
He has presented at the American Academy of Optometry (AAO), Association for Research in Vision and Ophthalmology (ARVO) and the British Contact Lens Association (BCLA). He is a Fellow of BCLA and AAO and a member of ARVO, Optometry Australia and the Cornea and Contact Lens Society of Australia.
Technology - Novel Instruments and Know How
- Lens parameter measurements in accordance with ISO
- Visualisation of optical zones and defects using unique Contact Lens Quality Analyser
- Measuring the shape of soft contact lenses, including base curve profile
- Assessment of contact lens optical performance for central and peripheral vision using life size model eye.
Developed and validated clinical assessment tools
- Electronic Vision Charts for distance, intermediate and near
- Testing of peripheral contrast sensitivity
- Dynamic vision assessment, i.e. vision after blink
- Peripheral refraction measurement
- Customised micro-tensometer to measure mechanical properties of contact lens materials under on-eye conditions
- Determination of equivalent water content
- Assessing surface wettability using meniscus height and meniscus force methods
- Spectral transmission and refractive index measurements
- Hydraulic conductivity of contact lens and related materials
- Optical Quality Analyser (1985)
- CRCERT-Belmonte Aesthesiometer (2000)
- Ex Vivo Accommodation Simulator (2005)
- Eye Tracker (2004)
- Micro-Tensometer (2004)
- Model Eye (2011)
- EyeMapper (2011)
- OCT Profilometer (2014)
- Friction Meter (2015)
- Modified Autorefractor (2007)
- Aberrometer (2009)
- Measuring Microscope (2013)
DIRECTOR OF TECHNOLOGY
Dr Klaus Ehrmann
BEng MSc PhD
Dr Ehrmann’s professional qualifications include a BEng awarded from the Aalen University of Applied Sciences, Germany (1986); an MSc in machine design from the Cranfield University, UK (1988) and a PhD in Biomedical Engineering from the University of New South Wales (1997).
For the last 17 years Dr Ehrmann has been responsible for instrument development and metrology at Brien Holden. His interests concentrate on developing innovative methods for vision correction and related instrumentation.
Dr Ehrmann is a member of the Australian working group on ISO standards related to intra ocular lenses. The physical model eye he co-developed has recently been recommended to be included as a reference in the updated draft of ISO 11979.
A successful transfer of the licenced technology involves ongoing support from Brien Holden Vision Institute to ensure seamless integration of the licensed technology into existing manufacturing processes.
This process, managed by Science and Technology Manager, Dr Fabian Conrad, involves the areas of design creation, quality control, clinical validation and testing, as well as marketing and regulatory support.
QUALITY CONTROL SOFTWARE
SCIENCE AND TECHNOLOGY MANAGER
Dr Conrad is a scientist in the areas of software development, contact lens design and myopia research.
He has extensive experience in developing novel technology and software for scientific research
Fabian completed his undergraduate studies in Optometry at the University of Applied Sciences in Berlin and his PhD at Brien Holden Vision Institute, through the University of New South Wales, Sydney, in 2010.
2016-2017 ANNUAL REVIEW
Our 2016-2017 Annual Review also contains some of our major achievements in the last financial year (July 2016 – June 2017) – the latest licencing agreements to convert our novel technology into commercial products, research discoveries providing new insights for practitioners and manufacturers, and how our people are making an impact.